The purpose of the study is to evaluate if supplementation with vitamin D in a dose of 40.000 IU per week will result in improved metabolic control in patients with type 2 diabetes.
The purpose of the study is to evaluate if supplementation with vitamin D in a dose of 40.000 IU per week will result in improved metabolic control in patients with type 2 diabetes. We will include 70 patients with type 2 diabetes. They will be treated with 40.000 IU cholecalciferol per week (or placebo) for 6 months. Metabolic control will be evaluated with measurements of glycated hemoglobin, home glucose measurements, and fasting blod glucose and serum insulin. Only subjects using insulin at bedtime combined with metformin during the day will be included.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
Cholecalciferol capsule 20.000 IU twice per week for 6 months
Placebo capsule twice a week, identical to the cholecalciferol capsules
Clinical Research Unit, University Hospital of North Norway
Tromsø, Tromsø, Norway
glycated hemoglobin
Time frame: 6 months
blood pressure
Time frame: 6 months
body weight
Time frame: 6 months
Hip/waist ratio
Time frame: 6 months
lipids
Time frame: 6 months
Hs-CRP
Time frame: 6 months
insulin sensitivity
Time frame: 6 months
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