A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweight and Obese Subjects

Inclusion Criteria: * Is obese with a Body Mass Index (BMI) \>=30 kg/m\^2 to \<=50 kg/m\^2 or overweight with a BMI \>=27 kg/m\^2 in the presence of other risk factors (e.g., hyperlipidemia, sleep apnea, or treatment for these conditions) * Has been obese or overweight for at least one year prior to study start * Either is not treated with or has been on a stable treatment regimen with any of the following medications for a minimum of 2 months prior to study start: \*hormone replacement therapy; \*oral contraceptives; \*lipid-lowering agents; \*thyroid replacement therapy; \*metformin Exclusion Criteria: * Is currently enrolled in or is planning to enroll in a formal weight-loss program * Is unwilling or unable to participate in a lifestyle intervention program as part of the study * Has been treated (within the 2 months prior to study start), is currently treated, or is expected to require or undergo treatment with any of the following excluded medications: \*prescription or over the counter antiobesity agents (within the 6 months prior to study start); \*psychotropic/neurological agents (i.e., antipsychotic, antiepileptic, antidepressant, or antianxiety agents, or mood stabilizers); \*steroids that are known to result in high systemic absorption; \*calcitonin; \*ketoconazole; \*antidiabetic medications * Has had liposuction, abdominoplasty, or a similar procedure within 1 year before study start or is planning to have such a procedure during the study * Has received any investigational drug within 1 month (or 5 half-lives of investigational drug, whichever is greater) before study start * Has previously used pramlintide either by prescription or as part of a clinical study * Has used sibutramine or phentermine (either by prescription or as part of a clinical study) within 2 years before study start * Has donated blood within 2 months before study start, or is planning to donate blood during the study