A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG

Inclusion Criteria: * Patients must be scheduled to undergo CABG surgery (during routine scheduling times) and had planned to use cardiopulmonary bypass. * Provide informed consent * Age ≥ 18 * Male patients, or female patients not of childbearing potential or who have had a negative pregnancy test and are practicing adequate contraception * Patients must be considered at high risk for subsequent myocardial complications defined as meeting 2 or more of the following: * Age ≥ 65 * Current or recent smoker (within last 6 months) * History of diabetes mellitus requiring treatment other than diet * Evidence of left ventricular dysfunction or congestive heart failure assessed by: * Ejection fraction (EF) ≤ 45% * Left ventricular end diastolic pressure (LVEDP) or pulmonary wedge pressure (PWP) ≥ 20 mm Hg * Pulmonary edema by chest X-ray * Cardiothoracic ratio \> 50% on chest X-ray * History of a previous non-disabling stroke, transient ischemic attack, or carotid endarterectomy * Urgent CABG intervention defined as the need to stay in the hospital (although patient may be operated on within a normal scheduling routine) * History of a myocardial infarction that occurred more than 48 hours but less than 6 weeks prior to CABG surgery * Prior peripheral artery surgery or angioplasty * Moderate renal dysfunction defined as creatinine clearance ≥ 30 ml/min, but \< 60 ml/min * Presence of at least one asymptomatic carotid artery stenosis (≥ 50%) either in one or two carotid arteries Exclusion Criteria: * Planned associated valve surgery or concurrent carotid endarterectomy * Planned aortic dissection repair or aortic root reconstruction * Screening visit occurring less than 4 hours before scheduled CABG surgery * Mini-Mental State Examination (MMSE) score less than 24 at the screening visit * Current cardiogenic shock, acute left ventricular rupture, ventricular septal rupture, or papillary muscle rupture * Uncontrolled diabetes defined as fasting serum blood glucose value equal to or greater than 24 mmol/L (432 mg/dl) at the time of screening (if fasting serum blood glucose not obtained at screening, values obtained within 30 days prior to screening visit may be used) * Myocardial infarction occurring \< 48 hours prior to planned CABG surgery * Severe renal dysfunction defined as an estimated creatinine clearance value of \< 30 ml/min or nephrotic syndrome at screening (or measured creatinine clearance value obtained within 30 days prior to screening visit) * History of liver cirrhosis, chronic active hepatitis (known positive serum test within 6 months of enrolment), or severe liver dysfunction; or liver transaminase ≥ 3 times upper limit of normal (ULN) at screening (or obtained within 30 days prior to screening visit). * History of malignancy during last 5 years except for basal cell carcinoma * Planned surgery for atrial fibrillation * Planned associated transmyocardial revascularization * Planned associated ventricular remodeling * Pregnancy or potential for pregnancy * Any medical or psychiatric condition which, in the opinion of the investigator, makes the patient an unsuitable candidate for the study * Significant, ongoing alcohol or drug abuse * Participation in any other investigational drug or device study within 30 days of randomization