A Study to Examine the Efficacy and Safety of Meridia® (Sibutramine Hydrochloride) in Binge-Eating Disorder

Inclusion Criteria: * Participants were men and women * between the ages of 18 and 65 * with Body Mass Index (BMI) \<45 kg/m2 * who met DSM-IV criteria for BED Exclusion Criteria: * Participants were excluded * for blood pressure \>140/90 mm Hg * with pulse \>95 beats/min * history of stroke, narrow angle glaucoma, cardiac disease, seizures, renal or hepatic dysfunction * use of insulin, medications known to affect body weight, or certain psychoactive medications (monoamine oxidase inhibitors, lithium, SSRIs, opioids) * current participation in a weight loss program * surgical treatment for obesity * bulimia nervosa or purging in the past 6 months * alcohol or drug abuse in the past 12 months * current psychiatric condition being treated with a psychoactive agent * current major depressive disorder * history of anorexia nervosa, psychosis, bipolar disorder, or suicide attempts * psychotherapy within the previous 2 months * Women were excluded if they were pregnant, lactating, or if fertile, not practicing adequate contraceptive precautions