The proposed study in an inception cohort of patients with hematological malignancies treated with PBSCT is designed to evaluate the effects of a physical exercise intervention on muscular-skeletal, physical activity and quality of life outcomes.
Peripheral Stem Cell Transplantation is a frequently used therapy option to increase survival in hematological and lymphatic malignancies. These malignancies and their treatment are associated with numerous physical and psychological symptoms and severe side effects. Physical exercise has been proposed as a promising strategy for the treatment of some of these physical and psychological complaints, and various exercise interventions are currently available after cancer treatment. To date, promising preliminary results concerning exercise programs in PBSCT recipients were published with limited sample size populations. Results of musculoskeletal outcomes in PBSCT recipients after cancer treatment are lacking.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
128
supervised exercise, 2 x / week
Hogeschool Utrecht, University of Professional Education, Faculty of Health Care, Chair of Lifestyle and Health
Utrecht, Netherlands
Cantonal Hospital Münsterlingen
Münsterlingen, Switzerland
Cantonal Hospital St.Gallen
Sankt Gallen, Switzerland
University Hospital Zurich
Zurich, Switzerland
Musculoskeletal performance
Time frame: Baseline -3 months - 6 months
Knee extension strength
Time frame: Baseline -3 months - 6 months
Grip Strength
Time frame: Baseline -3 months - 6 months
6 minute walk test
Time frame: Baseline -3 months - 6 months
15-meter walking speed
Time frame: Baseline -3 months - 6 months
and Health Related Quality of Life: (Physical function subscale of the EORTC-QLQ-C30 questionnaire).
Time frame: Baseline -3 months - 6 months
Role-,cognitive-,emotional-,social-,symptom scales and the global health and quality of life scale of the EORTC-QLQ-C30 Health Related Quality of Life questionnaire.
Time frame: Baseline -3 months - 6 months
Self-reported fatigue
Time frame: Baseline -3 months - 6 months
Self-reported and objectively assessed physical activity
Time frame: Baseline -3 months - 6 months
Whole body composition
Time frame: Baseline -3 months - 6 months
Haemotological values: e.g Hemoglobin
Time frame: Baseline -3 months - 6 months
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