A Study of Extended-Release Hydrocodone/Acetaminophen (Vicodin CR®) in Subjects With Acute Pain Following Bunionectomy

Inclusion Criteria: * Males and females ages 18 to 65 * Subject is scheduled to undergo primary, unilateral first metatarsal bunionectomy surgery * Meet specific pain intensity criteria on the morning after surgery * Willing to be confined for 4 days following surgery * If female, must be of non-child bearing potential or practicing birth control Exclusion Criteria: * Is allergic to or has a serious reaction to hydrocodone, acetaminophen, lidocaine, propofol, morphine sulfate, oxycodone, and/or similar drugs * Is allergic to or has a serious reaction to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) * Has a history of certain gastrointestinal diseases that may narrow or slow down the gastrointestinal tract * Has specific active or uncontrolled seizure disorders * Has been diagnosed with certain cancers within the past 5 years * Has a history of certain psychiatric disorders or requires treatment with certain drugs for depression * Has specific clinically significant illnesses or laboratory abnormalities * Has received corticosteroid treatment or any investigational drug within a specific timeframe