This study will evaluate the efficacy, safety and tolerability of two dosages of a new drug TPI ASM8 administered by inhalation for 14 days to mild to moderate asthmatic patients, aged between 18-65, non-smokers . The study will also look at the nature and quantity of inflammatory white cells in the lung secretions and in the blood, and some additional inflammation markers.
See above
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
10
Calgary COPD & Asthma Program
Calgary, Alberta, Canada
University of Alberta Hospital
Edmonton, Alberta, Canada
Gordon and Leslie Diamond Health Care Centre
Vancouver, British Columbia, Canada
Sputum eosinophils at Day 1 and Day 14 and safety on Day 14
Time frame: Prospective
FEV 1 on Day 1 and Day 14
Time frame: Prospective
Rescue Medication (albuterol)for 21 days
Time frame: Prospective
Gene expression ( mRNA, beta-chain and CCR3 on surface receptors of IL-3, IL-5 and GM-CSF
Time frame: Prospective
Blood eosinophils at Day 0 and Day 15
Time frame: Prospective
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St-Paul's Hospital
Vancouver, British Columbia, Canada
McMaster University Hospital
Hamilton, Ontario, Canada
Firestone Institute for Respiratory Health
Hamilton, Ontario, Canada
Kingston General Hospital
Kingston, Ontario, Canada
Institut Thoracique de Montreal
Montreal, Quebec, Canada
Hopital Sacre Coeur
Montreal, Quebec, Canada
Hopital Laval- Centre de recherche de Cardiologie et Pneumologie
Québec, Quebec, Canada