Imatinib Mesylate Combined With Intravitreal Ranibizumab in the Treatment of Choroidal Neovascularization Secondary to Age-Related Macular Degeneration

Inclusion Criteria: * Have a BCVA letter score in the study eye between 73-24 (approximately 20/40 to 20/320) using an ETDRS chart * Have a CNV lesion of any type in the study eye with the following characteristics as determined by fluorescein angiography: * Evidence that CNV extends under the geometric center of the foveal avascular zone. * The area of the CNV must occupy at least 50% of the total lesion. * The lesion must be ≤4000 microns in greatest linear dimension (GLD) * For occult with no classic CNV, the lesion must have presumed recent disease progression as assessed by the Investigator and defined as having at least one of the following criteria: * Blood associated with the lesion at baseline * Loss of VA in the previous 3 months defined as either * ≥5 letters (ETDRS equivalent) as determined by protocol refraction and protocol measurement OR- 2 or more lines using a Snellen or equivalent chart by standard examination * ≥10% increase in the GLD as assessed by fluorescein angiography in the previous 3 months Exclusion Criteria: * Have a history of prior PDT, external-beam radiation, subfoveal focal laser photocoagulation, submacular surgery, or transpupillary thermotherapy in the study eye * Have atrophy under the center of the fovea * Have angioid streaks, presumed ocular histoplasmosis syndrome, myopia (greater than 6 diopters), or choroidal neovascularization secondary to other causes than AMD * Are receiving or require chronic concomitant therapy with systemic (\> 5 mg) or ocular corticosteroids. Chronic concomitant therapy is defined as multiple doses taken daily for 14 or more consecutive days at any time within 6 months prior to screening * Inability to obtain photographs, fluorescein angiography, or optical coherence tomography to document CNV, e.g. due to media opacity, allergy to fluorescein dye or lack of venous access * Have received prior treatment with any anti-angiogenic compound or any investigational treatment (e.g. Macugen, Avastin \[bevacizumab\], Ruboxistaurin, Lucentis \[ranibizumab\], Retaane \[anecortave acetate\], squalamine, siRNA, VEGF-Trap etc.) for neovascular AMD * Have the presence of fibrosis, hemorrhage, pigment epithelial detachments, tear (rip) of the retinal pigment epithelium or other hypofluorescent lesions obscuring greater than 50% of the CNV lesion * Have any additional ocular diseases which have irreversibly compromised or follow-up could likely compromise the visual acuity of the study eye including amblyopia, anterior ischemic optic neuropathy, clinically significant diabetic macular edema, severe non-proliferative diabetic retinopathy * Within two months prior to screening, have had intraocular surgery (including cataract surgery) in the study eye * Within 1 month prior to screening had YAG laser in the study eye * Have had previous intravitreal drug delivery (injection or drug device implantation) in the study eye * Have had previous pars plana vitrectomy in the study eye * Have systemic cancer under active treatment with chemotherapeutic agents * Are being treated with anti-coagulants more than 325mg of aspirin per day. * Have hepatic insufficiency as defined as an SGOT greater than the upper limit of normal or a total bilirubin 1.5 times the upper limit of normal * Have history of congestive heart failure, myocardial infarction, transient ischemic attack and/or stroke within the last 3 months. * Are using herbal products such as St.Johns Wort, acetaminophen (Tylenol), eruthromycin, or phenytoin (Dilatin) on a chronic basis