A Study Testing the Effect and Safety of Casopitant (GW679769) While Taking Warfarin in Healthy Human Volunteers

Inclusion criteria: * Healthy subjects * non-smoking * Females cannot be able to have children * Must be able to swallow and retain oral medication * Understand and sign the written consent * comply with the requirements and restrictions involved in an overnight 30 day confinement in a healthcare setting Exclusion criteria: * cannot participate if subject has a clinically relevant abnormality, medical condition, or circumstance that makes them unsuitable for the study per the study doctor. * blood donation in excess of 1 pint within 56 days before dosing of medication * iron deficiency * history of drug or alcohol abuse or dependency within the past 6 months * subjects cannot use any nicotine-containing products within the last 6 months * positive for HIV, Hepatitis B or C * use of prescription or non-prescription drug(s), herbal or dietary supplements or vitamins with 14 days prior to first dose of study medication * consumption of any food or drink containing grapefruit, Seville oranges, kumquats, pomelos (or their juices) within 7 days of the first dose of study medication * history of bleeding disorders or excessive bleeding * female who has a positive pregnancy test * female who is lactating