A Study to Compare Mycophenolate Mofetil and Tacrolimus in the Treatment of Membranous Lupus Nephritis

Hospital Authority, Hong Kong20 enrolled

Overview

This is a prospective randomized open-label pilot study to compare mycophenolate mofetil in combination with corticosteroid treatment and tacrolimus in combination with corticosteroid treatment in membranous lupus nephritis. The change in urine protein excretion will be the primary outcome studied. The study duration will be 24 months for each patient.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Lupus Nephritis Glomerulonephritis, Membranous

Interventions

prednisolone and mycophenolate mofetilDRUG

prednisolone and tacrolimusDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * abnormal urine protein excretion and biopsy-proven membranous lupus nephritis

Locations (1)

Queen Mary Hospital

Hong Kong, China

Outcomes

Primary Outcomes

Proteinuria

Secondary Outcomes

Adverse effects

Data from ClinicalTrials.gov

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