A Pilot Study of Tumor Cell Vaccine for High-risk Solid Tumor Patients Following Stem Cell Transplantation

Eligibility Inclusion Criteria: To participate in this study, it is necessary to collect sufficient tumor and peripheral blood stem cells to both develop the vaccine and perform the autologous stem cell transplant. Patients who also have previously had tumor or stem cells collected, which are available and sufficient for this study, are eligible to participate as study subjects. 1. Patients must have a histologically verified diagnosis of neuroblastoma, Wilm's tumor, or sarcoma, including rhabdomyosarcoma, a Ewing's sarcoma family tumor (ES, PNET), synovial sarcoma, fibrosarcoma, or desmoplastic round cell tumor. and must meet one of the following criteria: 1. have metastatic disease at diagnosis 2. have never achieved complete remission following frontline standard therapy 3. have relapsed after receiving standard therapy 2. Patients must have been \< 30 years of age at the time of original diagnosis. 3. Patients must have a source of tumor tissue from which approximately 1 gram of viable tumor can be obtained for vaccine development. 4. Patients must have a good performance status (\>70% by Lansky or Karnofsky scales). 5. Patients must have a life expectancy of at least 16 weeks. 6. Females of child-bearing age (\>= 12 years old) must have a negative pregnancy test. Patients may enroll on this study at various points in their treatment including diagnosis, recurrence, or just prior to initiation of study mandated transplant therapy. Because patients may enter this study prior to completion of retransplant treatments, the below criteria must be met only to proceed to the high dose chemotherapy and autologous stem cell transplant part of this study. These criteria are not a requirement to enter this study in order to collect tumor or peripheral blood stem cells. 7. Patients must have achieved complete response or very good partial response(\>= 90% decrease in tumor volume) before proceeding to transplant. For patients enrolling on this study just prior to transplant a VGPR or CR must be achieved to be eligible. 8. Patients may have undergone prior autologous peripheral blood stem cell transplantation, provided at least 12 months have elapsed prior to entry on this study. 9. Patients must have had a successful peripheral blood stem cell collection, with cryopreservation of PBSCs for both engraftment and for generation of dendritic cells. 10. Adequate baseline organ function must be present: hematologic parameters (not applicable if bone marrow is involved with tumor): 1. ANC \> 500/mm3 2. platelet count \> 50,000/mm3 3. serum creatinine \< 1.5x upper limit of normal for age 4. serum hepatic transaminases (AST, ALT) \< 3x upper limit of normal 5. serum bilirubin \< 1.5x upper limit of normal 6. cardiac echocardiogram with either SF \> 27% or EF \> 50%. A comparable EF on a MUGA scan will also meet eligibility criteria. 11. Give or obtain informed consent Exclusion Criteria: 1. Patients who have received prior antitumor vaccines are ineligible 2. Patients who meet the response criteria but progress prior to study enrollment are ineligible 3. Patients with known autoimmune diseases or conditions are ineligible 4. Patients with HIV infection, AIDS, hepatitis B surface antigen positivity, ongoing bleeding, or any significant uncontrolled medical or psychiatric illness are ineligible. 5. Patients under treatment for infection must cleared by BMT physician prior to enrollment. 6. Patients who are pregnant or nursing are ineligible 7. Prior allogenic transplant