Pharmacokinetic Study Of Tigecycline In Adult Subjects With Primary Biliary Cirrhosis

Inclusion Criteria: * Men and nonlactating and nonpregnant women greater than or equal to 18 years of age * Subjects with biopsy proven primary biliary cirrhosis (PBC) disease in the asymptomatic or symptomatic phase of PBC. * Otherwise healthy as determined by the investigator on the basis of medical history, physical examination, clinical laboratory test results (other than those associated with PBC), vital signs, and 12-lead electrocardiogram (ECG). Exclusion Criteria: * Subjects with a recent increase in bilirubin, bilirubin \>15 mg/dL, presence of ascites, esophageal varices, or hepatic encephalopathy. * Any major illness that in the investigator's judgment will substantially increase the risk associated with the subject's participation in the study * Any malignancy including hepatocellular carcinoma.