SLV308 for Treatment of Patients With Parkinson's Disease Experiencing Motor Fluctuations

Inclusion Criteria: * Diagnosis of idiopathic Parkinson's Disease, * advance stage of disease, * Modified Hoehn \& Yahr stage II-IV, * presence of a recognizable 'on' and 'off' state (motor fluctuations) and stable treatment with levodopa for at least 28 days prior to randomization Exclusion Criteria: * 'on-off' phenomena or 'yo-yoing' and/or an abrupt unpredictable loss of efficacy unrelated to the timing of L-DOPA administration, * Prevalent expression of troublesome dyskinesias during 'on' time at waking hours, * Diagnosis is unclear or a suspicion of other parkinsonian syndromes exists, * Previous surgery for the treatment of PD