Factor Xa Inhibitor for Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement

Inclusion Criteria: * Scheduled for elective primary total knee replacement surgery * Legal minimum age requirement ( country-specific) * Written informed consent has been obtained Exclusion Criteria: * Documented history or considered to be at increased risk of venous thromboembolism * Subjects considered to be at increased risk of bleeding: * Known hemorrhagic disorder and/or coagulation disorder * Thrombocytopenia * Clinically important bleeding occurred within 3 months prior to the screening visit * Acute bacterial endocarditis * Severe hypertension * Retinopathy * Concomitant use of anticoagulants / antiplatelet agents (including homeopathic drugs) and/or anticipated postoperative need for other reasons than prevention of DVT during the study period.