Ocular Pulse Amplitude And Choroidal Laser Doppler Flowmetry

University Hospital, Basel, Switzerland10 enrolled

Overview

This study intends to investigate the relationship between choroidal blood flow and ocular pulse amplitude (OPA).

One eye is randomly selected in 18 healthy subjects. OPA is assessed with Dynamic Contour Tonometry. Submacular choroidal blood flow is measured with Laser Doppler Flowmetry. During both examinations the systemic blood pressure is continuously recorded with Finometer. An average systolic and diastolic LDF parameter flow during 30 seconds are determined and the pulsatility index is calculated according to the formula (LDFsys-LDFdia)/LDFdia. An association of OPA with the LDF pulsatility index, systemic blood pressure values and mean intraocular pressure will be analysed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy

Eligibility

Sex: ALLMin age: 45 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy subjects should present no history of ocular diseases, of current topical medication, or of drug or alcohol abuse. Furthermore, a best corrected visual acuity above 20/25 in both eyes, lack of pathological findings upon a slit-lamp examination and dilated direct fundoscopy, and an IOP \< 21 mmHg in both eyes will be required. Exclusion Criteria: * History of chronic or recurrent severe inflammatory eye disease such as scleritis or uveitis. * History of ocular trauma or intraocular surgery. History of infection or inflammation within the past 3 months. * History and clinical evidence for other retinal disease such as age-related degeneration, or diabetic retinopathy.

Locations (1)

University Eye Clinic Basel

Basel, Canton of Basel-City, Switzerland

Outcomes

Primary Outcomes

An association of OPA with the LDF pulsatility index

Time frame: 30 seconds

Secondary Outcomes

An association of OPA with the systemic blood pressure values

Time frame: 30 seconds

An association of OPA with mean intraocular pressure

Time frame: 30 seconds

Data from ClinicalTrials.gov

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