Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

University Hospital, Basel, Switzerland23 enrolled

Overview

Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sepsis

Eligibility

Sex: ALLMin age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Sepsis * Admission to ICU Exclusion Criteria: * CNS infection * History of cerebrovascular disease

Locations (1)

Operative Intensivbehandlung, University of Basel Hospital

Basel, Switzerland

Data from ClinicalTrials.gov

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