A Multi-Risk Factor Strategy vs a Guideline-Based Approach in Achieving Blood Pressure and Lipid Goals in Hypertensives at Extra Risk

Subjects With Blood Pressure of <140/90 mmHg and LDL-C <100 mg/dL at Week 4

Subjects achieving both the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC)-7 blood pressure goal of \<140/90 mmHg and the National Cholesterol Education Program Adult Treatment Panel (NCEP/ATP) III Update low density lipoprotein-cholesterol (LDL-C) goal \<100 mg/dL at Week 4.

Time frame: Week 4

Subjects With BP <140/90 mmHg and LDL-C <130 mg/dL at Week 4.

Subjects achieving both JNC-7 blood pressure goal of \<140/90 mmHg and NCEP/ATP III LDL-C goal \<130 mg/dL at Week 4.

Time frame: Week 4

Subjects With BP <140/90 mmHg and LDL-C <130 mg/dL at Week 6.

Subjects achieving both JNC-7 blood pressure goal of \<140/90 mmHg and NCEP/ATP III LDL-C goal \<130 mg/dL at Week 6.

Time frame: Week 6

Subjects With LDL-C < 100 mg/dL at Week 4

Subjects Who achieve a goal of LDL-C \< 100 mg/dL at Week 4.

Time frame: Week 4

Subjects With LDL-C < 100 mg/dL at Week 6

Subjects Who achieve a goal of LDL-C \< 100 mg/dL at Week 6.

Time frame: Week 6

Subjects With BP < 140/90 mmHg at Week 4

Subjects achieving BP goal of \<140/90 mmHg at week 4

Time frame: Week 4

Subjects With BP < 140/90 mmHg at Week 6

Subjects achieving BP goal of \<140/90 mmHg at week 6

Time frame: Week 6

Change From Baseline to Week 4 in Systolic Blood Pressure (SBP).

Mean at observation minus mean at baseline

Time frame: Week 4, baseline

Change From Baseline to Week 4 in Diastolic Blood Pressure (DBP)

Mean at observation minus mean at baseline

Time frame: Week 4, baseline

Change From Baseline to Week 4 in Pulse Rate

Mean at observation minus mean at baseline measured in beats per minute (bpm).

Time frame: Week 4, baseline

Change From Baseline to Week 6 in Systolic Blood Pressure (SBP)

Mean change at observation minus mean baseline.

Time frame: Week 6, baseline

Change From Baseline to Week 6 in Diastolic Blood Pressue (DBP)

Change from mean at observation minus mean at baseline

Time frame: Week 6, baseline

Change From Baseline to Week 6 in Pulse Rate

Mean at observation minus mean at baseline

Time frame: Week 6, baseline

Change From Baseline in LDL at Week 4.

Change: mean of observation minus mean at baseline.

Time frame: Week 4, baseline

Change From Baseline in High Density Lipoprotein (HDL) at Week 4.

Mean change at observation minus baseline.

Time frame: Week 4, baseline

Change in Total Cholesterol (TC) From Baseline to Week 4.

Mean change at observation minus baseline.

Time frame: Week 4, baseline

Change From Baseline in Triglycerides (TG) to Week 4.

Mean change at observation minus baseline

Time frame: Week 4, baseline

Change From Baseline in LDL at Week 6.

Mean change at observation minus baseline.

Time frame: Week 6, baseline

Change From Baseline in HDL at Week 6.

Mean change at observation minus baseline.

Time frame: Week 6, baseline

Change From Baseline in Total Cholesterol (TC) to Week 6.

Mean change at observation minus baseline.

Time frame: Week 6, baseline

Change From Baseline in Triglycerides (TG) at Week 6.

Mean change at observation minus mean baseline.

Time frame: Week 6 , baseline

Change From Baseline to Week 4 in Framingham Predicted Absolute 10-year Risk.

Framingham prediction of absolute 10-year risk of CHD outcomes (MI or CHD death) are calculations based on total point score (range less than negative 3 \[best\] to greater than or equal to 14 \[worst\] for men; less than or equal to negative 2 \[best\] and greater than or equal to 17 \[worst\] for women) of subject age, sex, current blood pressure treatment status, current smoking status, total cholesterol, high-density lipoprotein cholesterol and systolic blood pressure calculated at Week 4. Mean at observation minus mean at baseline.

Time frame: Week 4, baseline