Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects

Inclusion Criteria: * Healthy males and females ≥ 50 years * Body mass index equal to or greater than 18.5 kg/m2 and less than 35.0 kg/m2 Exclusion Criteria: * Known or suspected allergy to tolterodine ER or darifenacin or their components * Subjects with irregular day and night patterns such as night shift workers * Significant medical problems know to affect heart rate (ie., hypertension, hypotension, history of heart failure, history of pulmonary disease, etc.) * History of any malignancy within the past 5 years, with the exception of localized basal cell carcinoma of the skin * Pregnant or nursing women * Subjects with diseases such as urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, severe renal insufficiency, etc. Other protocol-defined inclusion/exclusion criteria may apply