Comparison of the Effect of 4th Generation Fluoroquinolones, Gatifloxacin and Moxifloxacin, on Epithelial Healing Following Photorefractive Keratectomy (PRK), A Substudy of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)

Walter Reed Army Medical Center40 enrolled

Overview

The purpose of this study is a prospective,double-blinded, randomized trial to compare the rate of healing following PRK after the use of two commercially available 4th generation fluoroquinolones, moxifloxacin and gatifloxacin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Epithelium, Corneal

Interventions

MoxifloxacinDRUG

1 drop 4 times daily for 1 week or until complete re-epithelization (usually 3-4 days) after surgery

Eligibility

Sex: ALLMin age: 21 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Manifest refraction spherical equivalent (MSE) of up to -6.00 diopters (D) at the spectacle plane with refractive cylinder up to 3.00D. Exclusion Criteria: * Concurrent topical or systemic medications that may impair healing including corticosteroids, antimetabolites, isotretinoin, amiodarone hydrochloride and/ or sumatripin. * Patients with known sensitivity or inappropriate responsiveness to any of the medications used in the post-operative course. * Anterior basement membrane dystrophy. * History of recurrent epithelial erosion. * Significant dry eye (symptomatic sith Schirmer \<5mm at 5 minutes) * Other corneal epithelial disorder or healing abnormality

Outcomes

Primary Outcomes

Corneal Epithelial Healing Time

patients' eyes will be observed daily after surgery until the corneal epithelium has completely healed (usually 3 to 4 days)

Time frame: 3 to 4 days after surgery