Testing of Innocuousness of Benzalkonium Chloride on the Eye Concerning Possible Growth of Langerhans Cells

University of Rostock20 enrolled

Overview

The study analysis the influence of benzalkonium chloride on the density of antigen presenting Langerhans cells. This is achieved in a double blind randomized study using in-vivo confocal microscopy to identify and quantify Langerhans cells of the human cornea in its central and peripheral part. This study design is based on observations with raised Langerhans cell density after the application of benzalkonium chloride containing eye drops in glaucoma patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Eye Diseases

Interventions

Benzalkonium chlorideDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy probands Exclusion Criteria: * eye diseases * pregnancy and lactation period * drug dependency

Locations (1)

University of Rostock, Eye Department

Rostock, Germany

RECRUITING

Outcomes

Primary Outcomes

Possible raised Langerhans cell density in the corneal epithelium

Data from ClinicalTrials.gov

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