Effects of AFQ056 and Nicotine in Reducing Cigarette Smoking

Inclusion Criteria: * Healthy, male \& female subjects at least 18 years and ≤60 years of age * In good health * Female subjects must be surgically sterilized or postmenopausal. * Current smokers not intending to quit * Smoke on average 15 cigarettes or more and less than 60 cigarettes a day for the past year * Fagerström Test for Nicotine Dependence score of at least 5 (indicates moderate to heavy smokers) * Willing to refrain from smoking as required * Written informed consent before entering the study Exclusion Criteria: * History of heart disease, septum defect and/or cardiac valves surgery; clinical relevant abnormality in the ECG * Investigational drug treatment within 4 weeks prior to screening unless local health authority guidelines mandate a longer period * Women of childbearing potential, pregnant or lactating females * Donation of one unit (400mL) or more of blood, significant blood loss equaling at least one unit of blood within the past 2 months or a blood transfusion within 8 weeks prior to screening. * Coffee consumption of more than 6 cups coffee/day * Use of a medication within 2 weeks prior to Day 1 of each treatment period Other protocol-defined inclusion/exclusion criteria may apply