Safety of and Immune Response to an HIV DNA Plasmid Vaccine Followed by HIV Adenoviral Vector Vaccine in Healthy African Adults

Inclusion Criteria: * At risk for HIV * Have had sexual intercourse with an HIV infected partner OR have had sexual intercourse with more than one person within the 3 months prior to study entry OR infected with a sexually transmitted disease within the 3 months prior to study entry * Willing to comply with the protocol * Willing to undergo HIV testing and HIV counseling and receive HIV test results * Willing to use acceptable forms of contraception Exclusion Criteria: * HIV-1 or HIV-2 infected * History of immunodeficiency or autoimmune disease * Use of corticosteroids or immunosuppressive, antiviral, anticancer, or other medications considered significant by investigator within 6 months prior to study entry * Certain abnormal laboratory values * Acute or chronic medical condition considered progressive * Hepatitis B or hepatitis C virus infection or untreated syphilis * Live attenuated vaccine within 30 days prior to study * Planned receipt of investigational product within 30 days after first vaccination * Other medically indicated subunit or killed vaccine within 14 days prior to study entry * Planned receipt of other medically killed vaccine investigational product within 14 days after first vaccination * Blood transfusion within 120 days of study entry * Immunoglobulin within 60 days of study entry * Participation within the last 3 months, or planned participation in another clinical study of investigational product currently or during the course of this study * Another investigational HIV vaccine at any time * History of severe local or systemic reactogenicity to vaccines * History of severe allergic reactions * History of recurrent urticaria * Major psychiatric illness, including any history of schizophrenia or severe psychosis, bipolar disorder requiring therapy, or suicide attempt or ideation in the 3 years prior to study entry * Uncontrolled hypertension * Pregnant, breastfeeding, or planning to become pregnant within 4 months following last study vaccination