Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals

Taichung Veterans General Hospital25 enrolled

Overview

To investigate whether weight reduction by life style modification for 12 weeks will improve circulating inflammatory markers, adipocytokines as well as gene expression of proinflammatory protein obtained from circulating monocytes from obese individuals.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

NONE

Enrollment

Conditions

Obesity Inflammation

Interventions

Lifestyle modificationBEHAVIORAL

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Nondiabetes obese individuals with BMI greater than 27 kgs/m2 Exclusion Criteria: * Diabetes * Abnormal hepatic, renal and cardiac function

Locations (1)

Taichung Veterans General Hospital

Taichung, Taiwan

Outcomes

Primary Outcomes

Inflammatory responses after weight reduction

Secondary Outcomes

BMI

Circulating inflammatory markers

Adipocytokines

Gene Expression from mononuclear cells

Data from ClinicalTrials.gov

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