Effects of FTY720 on Heart and Lung Functions in Healthy Volunteers

Inclusion Criteria: * Healthy, non-smoking,(ie. 6 months w/o the use of nicotine or nicotine containing products), male or female subjects. * Female subjects must be either surgically sterilized (including bilateral tubal ligation) at least 6 months or post-menopausal. Postmenopausal women must have no regular menstrual bleeding for at least 1 year prior to inclusion and menopause will be confirmed by a plasma FSH level of \>40 IU/L. * Male subjects agree to refrain from sperm donation from check-in until 30 days beyond the conclusion of all study events. * Male subjects must agree to the use of condoms with spermicide with sexual intercourse from 14 days prior to check-in until 30 days beyond the last dose of study drug. * Resting heart rate ≥ 50 beats per minute (bpm) Exclusion Criteria: * History or presence of any clinically significant events, which in the opinion of the investigator, would jeopardize the safety of the subject or impact the validity of the study results. * Subjects with systolic blood pressure \< 90 mmHg or diastolic blood pressure \< 50 mmHg * Male subjects with a QTcB \> 450 msec * Female subjects with a QTcB \> 470 msec * Subjects with pulmonary symptoms, history of exercise-induced asthma, asthma or chronic obstructive pulmonary disease (COPD) * Use of any prescription drug within 1 month of starting the study * Positive urine screen for alcohol or drugs at screening, unless the test is shown to be falsely positive on confirmation testing. * Hemoglobin \< 12g/dL * Donation of blood or significant blood loss within 56 days prior to check in. * Donation of plasma within 7 days prior check in. * Participation in an investigational study within 30 days prior to check in. * Positive screening test for HIV or Hepatitis B or C. * A past history of cigarette smoking of \> 10 pack-years or use of nicotine or nicotine-containing products 6 months prior to dosing. Other protocol-defined inclusion/exclusion criteria may apply