The purpose of this study is to investigate whether an angiotensin II receptor blocker (olmesartan), in addition to conventional treatment, will reduce the mortality and morbidity in hypertensive patients with stable chronic heart failure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
1,145
5 to 40mg P.O. daily until the end of the study
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
Sendai, Japan
A composite of the following outcomes 1) all-cause death 2) nonfatal acute myocardial infarction 3) nonfatal stroke 4) hospital admission due to congestive heart failure
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
cardiovascular death
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
death due to heart failure
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
sudden death
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
acute myocardial infarction
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
stroke
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
hospital admission from any cardiovascular reasons
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
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fatal arrhythmia or appropriate ICD discharge
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
new-onset diabetes
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
development of renal failure
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
new-onset atrial fibrillation
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
a need to modify treatment procedures for heart failure
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
left ventricular ejection fraction
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study
B-type natriuretic peptide
All the patients were enrolled by March, 2010, and were followed-up by the end of March, 2013.
Time frame: by the end of the study