Interruption of Dorsal Visual Stream Using TMS

Sheba Medical Center12 enrolled

Overview

Trans Cranial Magnetic Stimulation (TMS) over dorsal visual system will disturb the ability to identify objects with decreased level of fragmentation

The participants performed two tasks under three different TMS conditions: no TMS, 10Hz TMS for over the dorsal stream (PO3 EEG site) or over the vertex. First they performed a perceptual closure task which asked them to identify an object in a series of six progressively less degraded pictures. Then, they also performed a control task previously shown not to be mediated by the LOC and not to be impaired in schizophrenia: The perception of illusory contours.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

No TMS interventionDEVICE

In the "no TMS" condition, no simulation was given and no coil placed near participants' heads.

TMS over the PO3 EEG siteDEVICE

10Hz TMS over the dorsal stream (PO3 EEG site)

TMS over the vertexDEVICE

10Hz TMS for over vertex.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normal controls Exclusion Criteria: * neurological, ophthalmological or psychiatric problems * family history of schizophrenia * left handed

Locations (1)

Psychiatry Clinic - Sheba Medical Center

Tel Litwinsky, Israel

Outcomes

Primary Outcomes

Results of the study assignments performed by the participants during the study.

The subjects performed 2 tasks: The primary dependent measures consisted of the level of detail needed for correct object identification, response accuracy, and response time in milliseconds for correct responses. Illusory Contour Task: Subjects also performed a pulsed pedestal task, Participants were shown 55 drawings for 500 ms each. Some drawings contained partial contours which defined a geometric shape, while in others the contours did not define a shape. Participants were asked to indicate whether they recognized a geometric shape or not. Accuracy and response time were measured.

Time frame: The participants performed the tasks once during their study visit

Data from ClinicalTrials.gov

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