A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain

The change from Baseline to each day (Days 1 to 6) and over the average response in Days 1 to 6 using an 11 point numeric rating scale (NRS) from 0-10 on daily pain diary;

Time frame: (Days 1 to 6)

Patient's Global Impression of Change (PGIC) at Week 2;

Time frame: Week 2

The change from Baseline to Weeks 1 and 2 in the Patient's Global Assessment of Arthritic Condition;

Time frame: Baseline to Weeks 1 and 2

The change from Baseline to Week 1 (Day 7) in the WOMAC Pain domain score;

Time frame: Day 7

The change from Baseline to Weeks 1 and 2 (Days 7 and 14) in the WOMAC Stiffness domain score;

Time frame: Days 7 and 14

The change from Baseline to Weeks 1 and 2 (Days 7 and 14) in the WOMAC Physical Function domain score;

Time frame: Days 7 and 14

The change from Baseline to Weeks 1 and 2 (Days 7 and 14) in the WOMAC Total Score by simple summation;

Time frame: Days 7 and 14

The change from Baseline to Weeks 1 and 2 (Days 7 and 14) in the WOMAC Importance Weighted Total Score;