Zotepine Versus Risperidone in Aggressive Schizophrenic Patients of Acute Ward

Inclusion Criteria: * Aged 18 to 65 years, male or female * In-patients suffering from schizophrenia according to DSM-IV diagnostic criteria with PANSS total score of greater than or equal to 60. * Patients with PANSS-EC total score of greater than or equal to 14 and with at least one PANSS-EC symptom score greater than or equal to 4 Exclusion Criteria: * Patients with history of seizure or with alcohol or substance abuse in the last 6 months * Diabetes, Parkinson's disease or phaeochromocytoma * Patients with hypertension and current use of antihypertensive agents * Women who are pregnant, lactating or intend to become pregnant during the study period * Poor response to two different antipsychotics in full dose and full course or use of clozapine previously * Renal, hepatic, haematologic disease or other conditions may not suitable for the study based on investigator's evaluation