Improvement of Liver Function in Liver Cirrhosis Patients After Autologous Mesenchymal Stem Cell Injection:a Phase I-II Clinical Trial

Phase 2CompletedNCT00420134

Shahid Beheshti University of Medical Sciences30 enrolled

Overview

The methods for separation of mesenchymal stem cell were established in 2001. These cells can differentiate to osteocytes, hepatocytes, chondrocytes, myocytes and etc,. In this study the investigators try to separate mesenchymal stem cell from end stage liver disease, then these cells will be differentiated to progenitor of hepatocytes, finally , the investigators injected these cells into portal vein under ultrasound guide. The investigators determine the effects of injected cells in reestablishment of liver function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Liver Failure Cirrhosis

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria: * MELD score of at least 10 * Patent portal vein on color Doppler examination of the liver * Normal alpha-feto protein serum levels * Age more than 18 * Filling inform consent by patients and first degree family members Exclusion criteria: * Any evidence of hepatocellular carcinoma on liver ultrasound studies * Patients want to exclude from study

Locations (2)

Research Center for Gastroenterology and Liver Diseases

Tehran, Tehran Province, Iran

Research center of Gastroenterology and Liver Disease