The DANTE Trial. A Randomized Study on Lung Cancer Screening With Low-Dose Spiral Computed Tomography

Inclusion Criteria: * Male sex * Age 60-74 years * smokers of more than 20 cigarettes/day for at least 20 years (actual smokers or ex-smokers from no more than 10 years) Exclusion Criteria: * severe cardiopathy * advanced BPCO with chronic hypoxaemia (rest SatO2 \< 94%) * chronic severe renal insufficiency * hypertension not controlled with drugs * type 2 diabetes or other severe systemic disease * severe previous cerebrovascular lesions with permanent invalidity (not self-sufficient). * severe vascular lesions with repeated ictus, trophic lesions, or limb loss, if actual smoker * Dementia, psychosis, severe depression or maniac-depressive syndrome * actual or precedent neoplasia, excepted skin tumor not-melanoma or scaly cells laryngeal and buccal cavity tumor, N0, recovered from more than 10 years or other tumors recovered from more than 10 years * transplantation less than 5 years or with rejection episodes in the last 2 years * unable subjects