Imatinib in Adult Patients With Metastatic Ocular Melanoma

Inclusion Criteria: * Metastatic ocular melanoma * Age \> or = 18 years old * Measurable metastases \> or = 10 mm according to RECIST criteria * PS-WHO \< or = 1 or IK \> 70 percent * Normal hepatic function * PNN \> 1500/mm3, platelets \> or = 100 000/mm3 * Contraception * Informed consent signed Exclusion Criteria: * Patient with two prior lines of systemic treatment (chemotherapy, immunotherapy or association) * Other evolutive neoplasic disease * Severe hepatic insufficiency * Severe renal insufficiency * Somatic or psychiatric co-morbidity incompatible with the protocol * Leptomeningeal or cerebral metastatic dissemination * Pregnant or lactating woman * Other antitumoral treatment * Patient participating to another clinical trial with an experimental drug * Known hypersensitivity to Imatinib or one of its excipients * Resecable single metastasis