Early Diagnosis of Asthma in Young Children

Maastricht University Medical Center202 enrolled

Overview

The overall aim of the study is an early asthma diagnosis in young children by the use of non-invasive biomarkers of airway inflammation /oxidative stress in exhaled air, and early lung function measurements

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

202

Conditions

Asthma

Interventions

beclomethasondipropionateDRUG

2 x 100 ug dd for two months, via aerochamber

Eligibility

Sex: ALLMin age: 2 YearsMax age: 4 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Children aged 2-3 years, with recurrent respiratory symptoms suggestive of asthma * Children aged 2-3 years, with no or minor respiratory symptoms Exclusion Criteria: * Mental retardation * Cardiac anomalies * Congenital malformations * Other diseases of the lungs/airways * Chronic systemic inflammatory diseases like M. Crohn * The inability to perform lung function measurements and/or exhaled air collection

Locations (1)

Maastricht University Medical Centre

Maastricht, Limburg, Netherlands

Outcomes

Primary Outcomes

- definite asthma diagnosis - biomarkers in exhaled breath

Time frame: 6 years of age

Data from ClinicalTrials.gov

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