A Study To Investigate The Effects Of End Stage Renal Disease And Hemodialysis On The Pharmacokinetics Of Ropinirole

Inclusion: * Patients and subjects between 18-79 years old. * End stage renal patients who are consistently receiving dialysis for a minimum of 3.5 hours, three times per week, with hemodialysis blood flow rates of \>200mL/min may be eligible to enter the study. * Patients must also have systolic blood pressure 100-190mmHg and diastolic blood pressure \<120mmHg. * Healthy subjects must have systolic blood pressure 100-150mmHg. Exclusion: * Female subjects who are pregnant and/or breast-feeding must not participate in this study.