The Study of Nasonex® Compared With Placebo for the Relief of Symptoms Associated With Acute Bacterial Sinusitis When Used With Antibiotics (Study P04824AM3)

Inclusion Criteria: * Must be 12 years of age and older, of either sex, and of any race. * Must weigh at least 40 kg (88 lb). * Must be willing to give written informed consent and be able to adhere to dose and visit schedules. * Must have a clinical diagnosis of acute bacterial sinusitis. * Must be symptomatic at the Screening and Baseline Visits on the basis of subject assessments of major symptoms score. * Must have radiographic evidence of sinusitis on CT scans taken at Screening. * Must be in general good health and free of any clinically significant disease (other than sinusitis) that would interfere with the study schedule or procedures, or compromise the subject's safety. * A subject's clinical laboratory tests (hematology, blood chemistry, and urinalysis), vital signs, and electrocardiogram (ECG) recordings must be within normal limits or clinically acceptable to the investigator/qualified designee. Any test results that are questionable should be referred to the sponsor. * A female subject of child-bearing potential must have a negative serum pregnancy (beta-hCG) test at Screening. She must agree to use a medically accepted method of contraception throughout the entire study period. Postmenopausal women will be exempted from the use of contraception during the study. Documented absence of menses for at least 1 year will indicate that a female is postmenopausal. If a pre-menarche female subject begins menstruating during the study, a serum pregnancy test must be done at the next visit. A female subject of child-bearing potential who is not currently sexually active must agree to use a medically accepted method of contraception should she become sexually active while participating in the study. Exclusion Criteria: * A subject with moderate to severe persistent asthma that requires daily treatment with inhaled steroids, or an exacerbation of asthma within the past 30 days. * A history of chronic sinusitis (symptoms lasting greater than 3 months) or having undergone sinus or nasal surgery for chronic sinusitis or nasal polyps. * A history of symptomatic seasonal allergic rhinitis and who, during the study period, is living in or traveling to locations where the allergen to which he/she is allergic is present. * Subject with glaucoma or a history of posterior subcapsular cataracts. * Subject with nasal polyps visible upon physical examination, immotile cilia syndrome, immunodeficiency disease, cystic fibrosis, clinically significant cardiovascular (including rheumatic heart disease), pulmonary, renal, hepatic, metabolic, hematological or neurologic disease that in the investigator's judgment might interfere with the evaluation of the therapy, or subjects who are immunocompromised, in renal failure, or on dialysis. * Subject fails to observe the medication washout times outlined in the protocol prior to Screening. * Subject has an allergy to corticosteroids or penicillins. * Subject has used any investigational drug within 30 days of Screening. * Subject has a concurrent need for antibiotic therapy other than study drug (amoxicillin/clavulanic acid). * Subject is anticipating sinus or nasal surgery within the next month. * Subject has been previously randomized into this study. * Subject is part of the staff personnel directly involved with the study or is a family member of the investigational study staff involved in the study.