An Investigation To Determine The Potential Interaction Effect Between GW876008 And Midazolam.

Inclusion Criteria: * Healthy males or females. * Normal ECG. * Agree to remain in the clinic for the time defined in the protocol. * Subjects must agree to abstain from alcohol for 24 hours prior to the start of dosing until collection of the final pharmacokinetic sample. Exclusion Criteria: * Any serious medical disorder or condition. * Any history of an endocrine disorder. * Any clinically significant laboratory abnormality. * History of psychiatric illness. * Any history of suicidal attempts or behavior. * Active peptic ulcer disease. * Positive faecal occult blood. * The subject smokes or has smoked or has used any nicotine-containing products in the last six months. * Women having a positive serum HCG pregnancy test at screening, a positive urine pregnancy test before admission to the Unit during the in-house periods, who are not willing to use acceptable methods of contraception or who are lactating or planning to become pregnant within the three months following the screening visit.