Safety and Immunogenicity Study of an Inactivated Influenza Vaccine (Split Virus, Vero Cell Derived)

Inclusion Criteria: Male and female subjects who * Are 18 to 49 years of age (inclusive) on the day of screening (Stratum A) * Are 50 years of age or older on the day of screening (Stratum B) * Have an understanding of the study, agree to its provisions, and give written informed consent prior to study entry * Are clinically healthy (in a physical condition such that the physician would have no reservations administering influenza vaccine outside the scope of a clinical study) * Are physically and mentally capable of participating in the study * Agree to keep a daily record of symptoms * If female and capable of bearing children, have a negative urine pregnancy test result within 24 hours of the vaccination on Study Day 0 and agree to employ adequate birth control measures. For the purposes of this study adequate birth control measures incorporate 2 types of the following FDA approved birth control measures through 60 days after vaccination: * Hormonal types of birth control (such as implants, birth control pills, patches or other methods) or an intrauterine device, AND * An additional barrier type of birth control measure (i.e., condoms, diaphragms, cervical caps, etc.) Exclusion Criteria: Subjects who * Have previously been vaccinated against influenza with vaccine formulated for the 2006/2007 influenza season * Have an oral temperature \>=37.5°C at the time of vaccination on Day 0 (see note below) * Have Type I diabetes * Have a Body Mass Index \>35 * Have hypertension at screening (with or without medication) that is graded as greater than Stage 1 defined as a systolic pressure \>159 or diastolic pressure \>99 while seated and at rest (measurement may be repeated twice before subject is absolutely excluded) * Have clinically significant abnormal clinical laboratory values at screening * Have clinically significant electrocardiographic abnormalities at screening * Test positive for Human Immunodeficiency Virus(HIV), Hepatitis B Surface Antigen (HbsAg) or Hepatitis C Virus (HCV) * Have a history of cardiovascular disease that required hospitalization * Have a history of immunodeficiency or autoimmune diseases * Have a history of arthritis (joint swelling, tenderness, warmth or erythema) on more than one occasion, not related to trauma (including running) or any episode of non-trauma related arthritis within the previous 6 months * Suffer from active neoplastic disease or have a history of hematologic malignancy * Suffer from a disease or are undergoing a form of treatment that can be expected to influence immune response. Such treatment includes, but is not limited to systemic or high dose inhaled (\>800 μg/day of beclomethasone dipropionate or equivalent) corticosteroids, radiation treatment or other immunosuppressive or cytotoxic drugs * Have a history of inflammatory or degenerative neurological disease (e.g. Guillain Barré, multiple sclerosis) * Have received any vaccination within 2 weeks prior to vaccination in this study * Have received a blood transfusion or immunoglobulins within 30 days prior to vaccination in this study * Have donated blood or plasma within 30 days prior to vaccination in this study * Have a history of any vaccine related contraindicating event (e.g., anaphylaxis, allergy to eggs, allergy to components of the test or comparator vaccine, other known contraindications) * Have a rash, dermatologic condition or tattoos which may interfere with injection site reaction rating * Have a positive urine drug screen (unless the detected drug is currently prescribed by a licensed health care provider and the continued administration of the drug would not otherwise exclude the subject from participation) * Were administered an investigational drug within 6 weeks prior to study entry * Are concurrently participating in a clinical study that Inactivated Influenza Vaccine (Split Virus, Vero Cell Derived)includes the administration of an investigational product * Are a member of the team conducting this study * Are in a dependent relationship with the study investigator. Dependent relationships include close relatives (i.e., children, partner/spouse, siblings, parents) as well as employees of the investigator * If female, are pregnant or lactating. NOTE: If all other inclusion/exclusion criteria are met, a subject with a temperature \>=37.5°C on Day 0 may be included in the study at a repeat visit provided: 1. They do not have an oral temperature \>=37.5°C at the repeat visit, 2. The repeat visit is no more than 5 calendar days after the initial Day 0 visit, 3. The repeat visit is no more than 21 calendar days after all other screening procedures are completed, 4. Subjects are still being recruited at the study site.