This study will evaluate the pharmacokinetic profile, the effect of rennin inhibition and the relationship among pharmacokinetics, renin-angiotensin system (RAS) biomarkers, and blood pressure lowering effects of oral doses of SPP100 in Japanese patients with mild to moderate essential hypertension. Safety will also be evaluated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
34
Novartis Investigative Site
Tokyo, Japan
pharmacokinetic profile of aliskiren administration after meal Day 1, Day 14, and Day 28
effect of aliskiren on the RAS profile
relationship among steady state pharmacokinetics, change in RAS biomarkers and blood pressure lowering effect of aliskiren
safety
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