A Trial of Chemo & Radiation Therapy for Pancreatic Cancer

Inclusion Criteria: * Histological confirmation of pancreatic adenocarcinoma is required. * Only patients with unresectable, non-metastatic tumors are eligible. * Documentation of disease extent by endoscopic ultrasound and either laparotomy or laparoscopy must be performed within 42 days of registration. * All patients will also be assessed by chest x-ray and abdominal-pelvic CT scan. * Confirmation of palliative surgical bypass at the time of laparotomy or whether a biliary stent was placed will be requested. * Disease must be locoregional and not amenable to surgery based on one or more of the following criteria: * size of pancreatic tumor \> 5 cm. * lymph nodes (bulky, \> 2 cm, but within a radiation port) * vascular involvement or impingement of major vessels (superior mesenteric artery, superior mesenteric vein, portal vein, hepatic artery). * invasion into the adjacent structures. * Patients with either measurable or evaluable disease are eligible. * Patients with evidence of peritoneal seeding by malignancy are not eligible for the study. * Patients with other evidence of metastatic disease are not eligible. * Patients with concurrent malignancy of any site, except limited basal cell carcinoma or squamous cell carcinoma of the skin or carcinoma in situ of the cervix, are ineligible. * Patients with any other malignancy within 5 years of study entry, except curatively treated basal cell carcinoma or squamous cell carcinoma of the skin or carcinoma in situ of the cervix, are ineligible. * Patients may not have had prior therapy for carcinoma of the pancreas, nor prior abdominal radiation therapy. * Age \> 18 years. * CTC performance status \< 2. * No myocardial infarction in the past six months. * No major surgery in the past two weeks. * No uncontrolled serious medical or psychiatric illness. * Required Initial Laboratory Data: * Total bilirubin \< 2.0 mg/dl * AST \< 3x upper limits of normal. * Serum creatinine \< 2.0 mg/dl * WBC \> 3,000/mm3 (ANC\>1500/mm3) * Platelets \> 100,000 mm3 * CA 19-9 * Required Diagnostic procedures: * Chest X-ray * Abdominal pelvic CT scan * EUS * Staging laparoscopy or staging laparotomy Exclusion Criteria: Enrollment in this trial will be limited to patients for whom protocol therapy is safe and appropriate. Physicians should consider the risks and benefits of therapy together with all relevant medical and other considerations in deciding whether this protocol is appropriate for a particular patient. Specific considerations include: * Psychiatric illness which would prevent the patient from giving informed consent. * Serious medical illness such as uncontrolled infection, severe cardiovascular disease including recent (\< 6 months) myocardial infarction or uncontrolled congestive heart failure, or other serious illness which would limit anticipated survival to \< 12 weeks. * Protocol treatment would pose significant risk to an unborn child. Pregnant women should not be enrolled, and women of child-bearing age should be strongly encouraged to practice effective birth control during and for three months after the trial. * Inability to swallow medication. Patients should have adequate, unassisted oral intake.