Open Label Study of Duloxetine for the Treatment of Phantom Limb Pain

Inclusion Criteria: 1. Chronic PLP \> 6 months 2. Short-Form McGill Pain Questionnaire Sensory Pain Rating Index raw score ≥ 16 3. Age ≥ 18 years old 4. Inpatient or Outpatient 5. Able to come to all appointments, in the opinion of the investigator 6. Able to give informed consent, in opinion of investigator Exclusion Criteria: 1. Current Major Depressive disorder, Anxiety Disorder, or Psychotic disorder assessed by the Mini International Neuropsychiatric Interview (MINI) 2. Substance abuse or dependence within the last six months, as assessed by the MINI 3. Known Diabetes Mellitus to exclude diabetic peripheral neuropathy 4. History of coronary artery disease, hepatic disease, renal disease 5. Other pain syndromes 6. Any unstable medical conditions in the opinion of the investigator 7. Other psychotropic medications excluding hypnotics