The Efficacy and Safety of PerioChip Plus (Flurbiprofen/Chlorhexidine) Formulation in the Therapy of Adult Periodontitis

Inclusion Criteria: * Signed informed consent form * Good general health * Male or female subjects aged \>25 years old * Minimum of 8 natural teeth * Availability for the 25 weeks duration of the study * Periodontal disease on a natural teeth characterized by the presence of at least 2 teeth with periodontal pockets of 6-9 mm in depth (target teeth) in order to reach baseline (day 1) with periodontal pockets of 5-8 mm in depth, without involving the apex of the tooth. * Females of childbearing potential must be non pregnant at entry and agree to use an adequate method of birth control during the study. * Demonstrate bleeding on probing to the base of the pocket at the pockets (sites) selected at the time of screening. Exclusion Criteria: * Presence of oral local mechanical factors that could (in the opinion of the investigator) influences the outcome of the study. * Presence of orthodontic appliances or any removable appliance that impinges on the tissues being assessed. * Soft or hard tissue tumours of the oral cavity. * Presence of dental implant adjacent to target tooth. * Periodontal pockets of more than 9 mm in depth. * General systemic antibiotics therapy or periodontal/mechanical/local delivery therapy within 6 weeks prior to study entry and through out the study duration. * History of allergy to chlorhexidine, flurbiprofen or to other non-steroidal anti-inflammatory drugs (NSAIDs). * Subjects taking diphenylhydantoin, nifedepine and/or cyclosporine, which might influence the pattern of tissue response. * Subject treated with non-steroidal anti-inflammatory drugs (NSAIDs) within 14 days prior to entry into the study and through out the study duration. * Pregnant women or those planning to become pregnant or lactating women. * Presence of the following conditions: Type 1 diabetes, major recurrent aphtae, stomatitis and related oral pathologies. * The presence of any medical or psychiatric condition or any other condition that in the opinion of the investigator could affect the successful participation of the subject in the study. * Subject participates in any other clinical study 30 days prior to the start of the study and through out the study duration. * Subject uses chlorhexidine oral rinses/ mouthwashes on a regular basis.