Amphotericin B Suspension in Refractory Chronic Sinusitis

Inclusion Criteria: * Has a diagnosis of refractory, postsurgical chronic sinusitis * Has a documented history of chronic sinusitis symptoms for more than 12 weeks * A CT scan showing a certain level of mucosal thickening in at least 1 maxillary sinus * An endoscopy documenting the presence of inflammation and absence of stage 4 polyps * Ability to comply with the study requirements including the ability to administer a nasal lavage twice daily for 4 months * Females of childbearing potential must use adequate birth control methods and not plan to get pregnant during the course of the study. * Ability to read or speak English Exclusion Criteria: * Has a hypersensitivity to Amphotericin B or the compounds of any study medications * Is an immunosuppressed patient or is receiving disease modifying agents * Has an acute upper or lower respiratory illness * Has an acute exacerbation of chronic sinusitis within 1 month prior to randomization * Has used systemic antibiotic therapy for reasons other than acute sinusitis within 3 weeks prior to randomization * Has used any antibiotic therapy for acute complication of chronic sinusitis within 1 month prior to randomization * Has orbital or central nervous system complications * Has acute asthma at study initiation * Began using nasal corticosteroids or had a dosage change within 3 months prior to randomization * Has taken a dose of oral or intravenous steroids to treat any condition other than asthma within 1 month prior to randomization * Has used any systemic antifungal therapy within 3 months prior to randomization * Has used intranasal antifungal therapy for chronic sinusitis within 3 months prior to randomization * Currently has a clinically significant deviated nasal septum that has not been remedied by surgery * Has an anatomical abnormality which would significantly obstruct the nasal passages * Has cystic fibrosis * Is pregnant * Has stage 4 polyposis * Has any significant medical condition that in a doctor's opinion could affect the patient's participation in the trial * Has used any investigational product within 1 month of study initiation * Has a history of cancer other than treated squamous cell or basal cell carcinoma of the skin that has not been in full remission for at least 5 years prior to study initiation