Monitoring and Outcome Measures in Asthmatics and Smokers During Pregnancy

Inclusion Criteria: * Patients need to be pregnant to participate in the study. * Patients need to be aged 18 to 35 to participate in the study. * Smokers must have smoked over 100 cigarettes in their lifetime and currently smoke 5 or more cigarettes per day. * Asthmatics must be diagnosed with asthma and have a current prescription for an asthma medication such as albuterol or an inhaled steroid. Exclusion Criteria: Nonsmokers * Cannot have smoked more than 100 cigarettes in their lifetime or currently smoke. * Cannot have any other lung diseases such as asthma, emphysema (COPD), lung cancer, liver disease, cystic fibrosis or other significant respiratory diseases. * Cannot have been treated with oral steroids or had a respiratory infection in the 4 weeks before study entry. * Cannot have another illness that can significantly affect quality of life (such as depression or cancer). Smokers * Cannot have any other lung diseases such as emphysema (COPD), lung cancer, liver disease, cystic fibrosis or other significant respiratory diseases. * Cannot have been treated with oral steroids or had a respiratory infection in the 4 weeks before study entry. * Cannot have another illness that can significantly affect quality of life (such as depression or cancer). Asthmatics * Patients in the asthma group cannot have taken theophylline (Theo-24, Theolair, Uniphyl) within 6 months of this study. * Asthmatics cannot have smoked over 100 cigarettes in their lifetime or be current smokers. * Cannot have any other lung diseases such as emphysema (COPD), lung cancer, liver disease, cystic fibrosis or other significant respiratory diseases. * Cannot have been treated with oral steroids or had a respiratory infection in the 4 weeks before study entry. * Cannot have another illness that can significantly affect quality of life (such as depression or cancer). All Subjects * All subjects will be required to avoid antihistamines for 5 days prior to skin testing (can cause false negative results). * All subjects will be required to avoid food, drink, exercise, and smoking 1 hour prior to exhaled nitric oxide measurement (could falsely increase or decrease levels), and will need to avoid foods that have a high nitrate content for 24 hours prior to exhaled nitric oxide measurement.