Study Evaluating Sirolimus and Cyclosporine in Kidney Transplant Recipients

Inclusion Criteria: * End-stage renal disease, with patients receiving a primary or secondary renal allograft from a cadaveric donor, from a living-unrelated donor, or from a living-related (excluding 0 antigen mismatch) donor. * Women who are of childbearing potential must have a negative pregnancy test before sirolimus administration and agree to use a medically acceptable method of contraception throughout the treatment period and for 3 months following discontinuation of sirolimus Exclusion Criteria: * Evidence of active systemic or localized major infection at the time of initial sirolimus administration * Evidence of infiltrate, cavitation, or consolidation on chest x-ray obtained during pre-study screening. * Chronic antiarrhythmic therapy for ventricular arrhythmia or other cardiac abnormality contraindicating general anesthesia or surgery