Neuromuscular and Cognitive Fatigue During a 24 Hour Treadmill Running Exercise

Centre Hospitalier Universitaire de Saint Etienne30 enrolled

Overview

The main purpose of the present study is to determine the relative contributions of central and peripheral fatigue during an ultra-endurance exercise.

For that purpose, 14 subjects running 24 hours on a treadmill will be compared with a control group being awake during the same period. Subjects who running will have electrically evoked forces on the muscles associated EMG activity, blood samples and muscle biopsy.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

running during 24 hours without sleepPROCEDURE

patients running during 24 hours without sleep

no sleepingOTHER

patients without sleep during 24 hours

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The subjects of the experimental group will be recruited among experienced ultra-runners . They all have run at least a 12 hour race or longer. * The control group will be recruited among experienced ultra-runners . Age of control group will be age experimental group more or less 2 years. Exclusion Criteria: * The subjects will not be selected if: * they were injured in the 3 months before the experiment * they had a tendon or joint pathology that could impair strength measurements. * they participate to an other experiment at the same time

Locations (1)

Pr André GEYSSANT

Saint-Etienne, France

Outcomes

Primary Outcomes

-Voluntary and electrically evoked forces on the contracted muscles

Time frame: 24 hours

Secondary Outcomes

Electrically evoked forces on the relaxed muscles and associated EMG activity

Time frame: 24 hours

Blood samples before the exercise

Time frame: every 4 hours

Muscle biopsy (vastus lateralis)

Time frame: before and after the exercise

Data from ClinicalTrials.gov

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