Radiotherapy for Malignant Astrocytomas in the Elderly

Assistance Publique - Hôpitaux de Paris

Overview

A randomized trial comparing radiotherapy with supportive care in patients aged 70 years or older with newly diagnosed, histologically confirmed anaplastic astrocytoma or glioblastoma, and a Karnofsky performance status \> 70.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Primary Brain Tumor Anaplastic Astrocytoma Glioblastoma Multiforme

Interventions

RadiotherapyDRUG

Eligibility

Sex: ALLMin age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Glioblastoma and anaplastic astrocytoma, supratentorial, histologically confirmed * Brain CT scan or MRI within 28 days before surgery * Age: 70 years or older * Karnofsky performance status, 70 or more. * Life expectancy over 12 weeks * Informed consent Exclusion Criteria: * Brain radiotherapy * Chemotherapy * Severe systemic disease

Locations (1)

Hôpital de la Salpêtrière

Paris, Île-de-France Region, France

Outcomes

Primary Outcomes

Survival

Secondary Outcomes

Progression free survival

Quality of life

Cognitive functions

Data from ClinicalTrials.gov

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