Valproic Acid Sodium Salt in Bipolar Disorder

Inclusion Criteria: * diagnosis of type I or II bipolar disorder according to DSM-IV after stratified SCID I interview, * being currently euthimic (for at least one month), manic-hypomanic and having YMRS points of 15 or more, or being in depressive episode and having HAM-D21 points of 15 or more * being not taking drugs for at least two weeks before participating in the study (except benzodiazepins) Exclusion Criteria: * female who are pregnant or planning to be pregnant, nursing * having known hypersensitivity to study drug * being given any psychotropic agent other than benzodiazepine within the last two weeks * active sustance or alcohol usage within the last two weeks, or substance addiction other than cafein or nicotine (within the last month) * having another axis I disorder such as comorbid dementia, delirium, obsessive compulsive disorder, eating disorder * having unstabilised hepatic or renal disorder, thyroid or blood disease * having history of cerebral surgery * existence of a degenerative neurologic disease or epilepsy * having pacemaker * having a prosthesis able to magnetic effect in eye, brain or sites near to these regions * homicide thougths or severe catatonia required to be hospitalized * having mixed episode The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.