Efficacy and Safety of SR58611A co-Administered With Escitalopram in Adults With Major Depressive Disorder

Inclusion Criteria: * Inpatients or outpatients with Major Depressive Disorder characterized by a recurrent Major Depressive Episode with Montgomery and Asberg Depression Rating Scale (MADRS) total score =\> 30 Exclusion Criteria: * Patient is at immediate risk for suicidal behavior * Patient with psychotic features, catatonic features, seasonal pattern or postpartum onset * Patients with a current depressive episode secondary to a general medical disorder * Patients with a lifetime history or presence of bipolar disorder, psychotic disorder, panic disorder and antisocial personality disorder * Patients with severe or unstable concomitant medical conditions * Pregnant, breastfeeding, or likely to become pregnant during the study * Treated with escitalopram within 6 months before the study, or who have had an adverse reaction to escitalopram The investigator will evaluate whether there are other reasons why a patient may not participate.