Trial of MitoQ for Raised Liver Enzymes Due to Hepatitis C

Inclusion Criteria: 1. Willing to adhere to study requirements as evidenced by providing written informed consent before initiation of any study-related procedures 2. Aged between 18-65 years 3. Documented history of chronic HCV infection (for at least 6 months prior to study entry) as diagnosed by either: 1. Anti-HCV positive or 2. HCV RNA viral load positive by PCR 4. Be a non-responder to or unsuitable for interferon based therapy. 5. Have liver inflammation, as defined by either AST and/or ALT levels 2-10 x ULN on at least 1 previous occasion within the past 6 months and at Pre-treatment visit 6. alpha-fetoprotein (AFP) less than/equal to 50µg/L 7. Hemoglobin ≥100g/L, platelet count ≥75x109/L, and white blood cell count ≥1.5x109/L 8. Males, or females who are not of child-bearing potential or who are taking adequate contraceptive measures. Female patients must be postmenopausal for at least 2 years prior to the study, surgically sterile, or using effective contraception for at least 2 months prior to starting study drug and until 28 days following the last dose of study drug. Acceptable methods of birth control include hormonal contraceptives, or double-barrier methods.Negative serum pregnancy test must be documented at the Pre-treatment visit (i.e. within 14 days of starting study drug) 9. Liver biopsy within past 3 years showing stage 2 fibrosis only (i.e. excludes cirrhosis and cancer); or within past 6 years showing stage 0 or 1 (no or minimal scarring). Exclusion Criteria: 1. Hepatocellular carcinoma (HCC) or suspicion of HCC clinically or on ultrasound (or other imaging techniques) 2. Presence of human immunodeficiency virus (HIV) 3. Co-infection with hepatitis B virus (HBV) 4. Last baseline AST and ALT level prior to Day 1 of \<2.0xULN 5. Renal impairment (creatinine\>1.5 x ULN) or hepatorenal syndrome 6. Chronic pancreatitis 7. Hospitalization for liver disease within 60 days of the Pre-treatment visit 8. Liver transplant recipients 9. Use of drug therapy for Hepatitis C, including the use of: 1. drugs with presumed anti-Hepatitis C activity in the past 3 months 2. corticosteroids in the past 30 days 3. drugs with medium to high risk of hepatotoxicity (including alpha methyl-dopa, sodium valproic acid, isoniazide, or nitrofurantoin) in the past 30 days 10. Any patient who admits to using or has a positive screening test for: amphetamines, barbiturates, pethidine, benzodiazepine, cocaine, methadone, opiates, phencyclidine or propoxyphene (unless medically prescribed and in stable doses for at least 30 days) 11. Alcohol consumption \>5 units per week 12. Any patient who has received any investigational drug or device within 30 days of dosing, or who is scheduled to receive another investigational drug or device during the course of this trial 13. History of a malignancy other than treated basal cell or squamous cell carcinoma of the skin; those with a history of malignancy that has been treated with no recurrence within the last 2 years are not excluded 14. Use of antioxidants (Coenzyme Q10 and idebenone) at doses ≥300mg/day within 120 days prior to enrolment. Doses between 25-300mg/day are not an exclusion and require a 7 day washout prior to study enrolment 15. Use of dietary supplements (vitamin or mineral) at constant doses throughout the study (unless medically prescribed). Patients choosing to stop using supplements are not excluded and require a 7 day washout period prior to study enrolment 16. History of a hypersensitivity reaction to any components of the study drug or structurally similar compounds including Coenzyme Q10 and idebenone 17. Unable to swallow tablets whole.