Study Of Safety, Blood Levels, And Brain Receptor Occupancy Of GSK163090 Using PET Imaging In Healthy Males

Inclusion Criteria: * Healthy male subjects, aged 18-45 years Body weight \> 50 kg * Non-Smoker * Normal ECG, heart rate and blood pressure Exclusion Criteria: * History of any cardiac disease * History of regular alcohol consumption averaging \>14 drinks/week * Current or recent gastrointestinal disease; History of psychiatric illness including any history of suicidal attempts * Positive for Hepatitis B and C, and HIV. * History of drug abuse. * Exposure to research and/or medical protocol involving nuclear medicine, PET or radiological investigations with significant radiation burden * Family history of cancer (one or more first-degree relative diagnosed before the age of 55). * Suffers from claustrophobia * History or presence of neurological or psychiatric conditions * Presence of a cardiac pacemaker or other implanted electronic device or metal implants