Lopinavir Capsules to Kaletra or Invirase Tablets

Inclusion Criteria: * Male or non-pregnant, non-nursing females \>18 years of age * Seropositive for HIV-1 * On an antiretroviral combination of Kaletra® with 2 nucleoside/nucleotide analogues for at least 6 months * HIV-1 RNA viral load \<50 copies/mL (2 consecutive measurements in the prior 6 months) plus screening viral load \<50 copies/ml. * Ability and willingness to provide written informed consent and adhere to the study regimen * Females of childbearing potential must have a documented negative serum or urine pregnancy test at screening/baseline and ensure that 2 reliable forms of contraception are being used, including a barrier method, for the duration of the study and for 90 days after the last dose of study medication Exclusion Criteria: * Documented virological failure on a protease inhibitor ARV regimen prior to commencing Kaletra® regimen * Documented protease mutation (one or more from the following list) prior to commencing Kaletra® regimen: * M46I/L/V, I47A/V, G48V/M, I50V, F53L/Y, I54L/M/V/A/T/S, V82A/T/S/F/M/L, I84A/V/C, L90M * Patients with acute hepatitis B or C infection * Females who are pregnant, breast-feeding, or who plan to become pregnant or breast-feed during the study· * Significant renal dysfunction (creatinine clearance \[CrCl\] \<60 mL/min) and/or hepatic impairment (aspartate aminotransferase/alanine aminotransferase \[AST/ALT\] \>3 X ULN and/or documented liver cirrhosis) Note: The site will calculate each patient's CrCl using the Cockcroft-Gault formula \[28\] as shown below: CrCl = \[140 - age (yr)\] × weight (kg) × constant 72 × serum creatinine (Cr) (mg/dL) where, constant = 1 for men and 0.85 for women * Any current known clinical or laboratory parameter of ACTG Grade 4 (see Appendix 4). However, asymptomatic Grade 4 abnormalities will be permitted at the discretion of the investigator if deemed clinically appropriate. Abnormalities deemed insignificant by the investigator must be discussed with the sponsor prior to enrollment. * Evidence of active, untreated opportunistic infection, intercurrent illness, drug toxicity or any other condition such that in the judgment of the investigator the patient would not be able to take or continue a prescribed antiretroviral regimen * Malignancy requiring chemotherapy or radiotherapy * Known hypersensitivity to any of the prescribed antiretroviral drugs or formulation components * Evidence of alcohol and/or drug or substance abuse that in the judgment of the investigator would likely result in the patient being unreliable in fulfilling the conditions of the protocol * History of psychological illness or conditions that in the judgment of the investigator might interfere with the patient's ability to understand the requirements of the study * History of drug non-adherence that in the judgment of the investigator would result in the patient being unreliable in fulfilling the conditions of this protocol * Patients who had received an investigational new drug within the last 4 weeks * Currently taking, or anticipate taking during the course of the study, any drug contraindicated with the antiretroviral drugs they have been randomized to receive